BCG induced murine peritoneal exudate cells: cytotoxic activity against a syngeneic bladder tumor cell line

J Urol. 1982 Jun;127(6):1225-9. doi: 10.1016/s0022-5347(17)54303-7.

Abstract

Peritoneal exudate cells from mice after intraperitoneal injection of 10 mg. of BCG demonstrated cytolytic activity in vitro against the syngeneic bladder tumor cell line MBT-2. The cytolytic effector cells are nonadherent, nonphagocytic and trypsin resistant. Moreover these cells are cyclophosphamide and hydrocortisone sensitive. It is suggested that an NK-like cell constitutes the major, if not all the population of effector cells in this reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibody-Dependent Cell Cytotoxicity
  • Ascitic Fluid / cytology
  • Ascitic Fluid / immunology
  • BCG Vaccine / pharmacology*
  • Cell Line
  • Cyclophosphamide / pharmacology
  • Cytotoxicity, Immunologic* / drug effects
  • Female
  • Hydrocortisone / pharmacology
  • Killer Cells, Natural / physiology*
  • Macrophages / physiology
  • Mice
  • Mice, Inbred C3H
  • Neoplasms, Experimental / immunology
  • Neoplasms, Experimental / therapy
  • Urinary Bladder Neoplasms / immunology*
  • Urinary Bladder Neoplasms / therapy

Substances

  • BCG Vaccine
  • Cyclophosphamide
  • Hydrocortisone