Abstract
Peritoneal exudate cells from mice after intraperitoneal injection of 10 mg. of BCG demonstrated cytolytic activity in vitro against the syngeneic bladder tumor cell line MBT-2. The cytolytic effector cells are nonadherent, nonphagocytic and trypsin resistant. Moreover these cells are cyclophosphamide and hydrocortisone sensitive. It is suggested that an NK-like cell constitutes the major, if not all the population of effector cells in this reaction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibody-Dependent Cell Cytotoxicity
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Ascitic Fluid / cytology
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Ascitic Fluid / immunology
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BCG Vaccine / pharmacology*
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Cell Line
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Cyclophosphamide / pharmacology
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Cytotoxicity, Immunologic* / drug effects
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Female
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Hydrocortisone / pharmacology
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Killer Cells, Natural / physiology*
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Macrophages / physiology
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Mice
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Mice, Inbred C3H
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Neoplasms, Experimental / immunology
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Neoplasms, Experimental / therapy
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Urinary Bladder Neoplasms / immunology*
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Urinary Bladder Neoplasms / therapy
Substances
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BCG Vaccine
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Cyclophosphamide
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Hydrocortisone