Natural history of "high-risk" bundle-branch block: final report of a prospective study

N Engl J Med. 1982 Jul 15;307(3):137-43. doi: 10.1056/NEJM198207153070301.

Abstract

We conducted a prospective study in which 554 patients with chronic bifascicular and trifascicular conduction abnormalities were followed for an average of 42.4 +/- 8.5 months. Heart block occurred in 19 patients, and 17 were successfully treated. The actuarial five-year mortality from an event that could conceivably have been a bradyarrhythmia was 6 per cent (35 per cent from all causes). Of the 160 deaths 67 (42 per cent) were sudden; most of these were not ascribable to bradyarrhythmia but to tachyarrhythmia and myocardial infarction. Mortality was higher in patients with coronary-artery disease (P less than 0.01) and congestive heart failure (P less than 0.05). Patients in whom syncope developed before or after entry into the study had a 17 per cent incidence of heart block (2 per cent in those without syncope)(P less than 0.05); however, no single variable was predictive of which patients were at high risk of death from a bradyarrhythmia. The predictors of death were increasing age, congestive heart failure, and coronary-artery disease; the predictors of sudden death were coronary-artery disease and increasing age. The risks of heart block and of death from a bradyarrhythmia are low; in most patients, heart block can be recognized and successfully treated with a pacemaker.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Arrhythmias, Cardiac / complications
  • Arrhythmias, Cardiac / mortality
  • Bradycardia / complications
  • Bundle-Branch Block / complications*
  • Bundle-Branch Block / mortality
  • Bundle-Branch Block / physiopathology
  • Coronary Disease / complications
  • Death, Sudden / epidemiology
  • Electrocardiography
  • Electrophysiology
  • Female
  • Follow-Up Studies
  • Heart Block / etiology*
  • Heart Block / therapy
  • Heart Failure / complications
  • Humans
  • Male
  • Middle Aged
  • Pacemaker, Artificial
  • Prospective Studies
  • Risk
  • Syncope / complications