Chemotherapy before and after mastectomy in stage III breast cancer

Arch Surg. 1982 Jul;117(7):879-81. doi: 10.1001/archsurg.1982.01380310005002.


Seventeen patients with stage III breast cancer were treated by modified radical mastectomy preceded and followed by multiagent cytotoxic chemotherapy. The preoperative treatment resulted in a decrease in size of the primary tumor, facilitating the subsequent surgical procedure. There were no serious surgical complications. Wound healing was uneventful. Median disease-free survival time was 29 months and median survival time was 40+ months. Six of the 17 patients are living free of recurrence from more than 33 to more than 79 months after initial therapy.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents / administration & dosage*
  • BCG Vaccine / therapeutic use
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / mortality
  • Breast Neoplasms / pathology
  • Breast Neoplasms / surgery*
  • Drug Therapy, Combination
  • Female
  • Humans
  • Mastectomy*
  • Menopause
  • Middle Aged
  • Neoplasm Staging
  • Postoperative Care
  • Preoperative Care
  • Time Factors


  • Antineoplastic Agents
  • BCG Vaccine