Effect of selenium on growth rate of canine mammary carcinoma cells in athymic nude mice

Cancer Lett. 1982 Feb;15(2):137-43. doi: 10.1016/0304-3835(82)90043-x.

Abstract

A canine mammary tumor cell line established from a carcinoma of the solid type was used in this study. In 2 separate experiments, athymic nude mice were inoculated subcutaneously with 5 x 10(6) viable tumor cells. All tumor-bearing mice received subcutaneous injections thrice weekly of 2 micrograms/g body wt of selenium as sodium selenite or phosphate buffered saline. Control, non-tumor-bearing mice were injected with either selenium or buffer. Selenium administration did not significantly alter the growth of non-tumor-bearing mice. However, body weight of tumor-bearing mice was reduced approximately 10%. The average volume of tumors in selenium treated mice was reduced 76% in experiment I and 74% in experiment II.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Body Weight / drug effects
  • Dogs
  • Female
  • Intestines / analysis
  • Kidney / analysis
  • Liver / analysis
  • Mammary Neoplasms, Experimental / analysis
  • Mammary Neoplasms, Experimental / pathology*
  • Mice
  • Mice, Nude
  • Selenium / blood
  • Selenium / pharmacology*
  • Time Factors

Substances

  • Selenium