Early detection of scleroderma-spectrum disorders by in vivo capillary microscopy: a prospective study of patients with Raynaud's phenomenon

J Rheumatol. 1982 Mar-Apr;9(2):289-91.


The condition of 25 patients with Raynaud's phenomenon, initially examined by in vivo capillary microscopy, was followed to determine how those who had shown scleroderma-pattern (SD-pattern) capillary abnormalities compared with other patients later in the course of disease. Limited follow-up information was obtained on 19 patients (10 with and 9 without the SD-pattern); the interval between the initial examination and the follow-up ranged from 9 months to 5 years. The results revealed that during the interval, 5 of the 10 patients who had initially displayed SD-pattern capillary abnormalities had developed SD (systemic sclerosis) or a closely related disease, but none of the 9 others. The length of the follow-up was comparable in both groups.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Capillaries / pathology*
  • Female
  • Fingers
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Raynaud Disease / pathology*
  • Scleroderma, Systemic / diagnosis*
  • Skin / blood supply
  • Time Factors