Neonatal seizures. I. Correlation of prenatal and perinatal events with outcomes

Pediatrics. 1982 Aug;70(2):165-76.


A review of 277 newborns with neonatal seizures enrolled in the Collaborative Perinatal Project revealed a mortality of 34.8%. Of the 181 survivors, most followed up to age 7 years, 70% were normal. Thus, despite the fact that seizures are a major indicator of perinatal asphyxia and a predictor of subsequent neurologic deficit, most infants with neonatal seizures who survived did well. Thirteen percent had cerebral palsy, 19% had an IQ less than 70, and 20% had epilepsy. Thirteen percent of survivors had a combination of mental retardation, cerebral palsy, or epilepsy. A low Apgar score, the need for resuscitation after 5 minutes of age, low birth weight, and the early onset of seizures or prolonged seizures correlated with adverse outcome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apgar Score
  • Cerebral Palsy / complications
  • Child
  • Child, Preschool
  • Epilepsy / complications
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Newborn, Diseases / complications*
  • Infant, Newborn, Diseases / diagnosis
  • Infant, Newborn, Diseases / mortality
  • Intellectual Disability / complications
  • Male
  • Seizures / complications*
  • Seizures / diagnosis
  • Seizures / mortality