Stability of antimicrobial agents in peritoneal dialysate

Antimicrob Agents Chemother. 1982 Mar;21(3):528-9. doi: 10.1128/AAC.21.3.528.

Abstract

The stability of cephapirin, gentamicin, penicillin G, nafcillin, ticarcillin, and vancomycin was tested in peritoneal dialysate at 25 degrees C for 24 h. All of the antimicrobial agents were stable except penicillin G, which lost 25% of activity over 24 h (P less than 0.01). The once-daily preparation of drug-dialysate solution is feasible for the treatment of peritonitis in patients on continuous ambulatory peritoneal dialysis.

MeSH terms

  • Anti-Bacterial Agents / analysis*
  • Drug Stability
  • Peritoneal Dialysis*

Substances

  • Anti-Bacterial Agents