Pilar neurocristic hamartoma: its relationship to blue nevus and equine melanotic disease

Arch Dermatol. 1982 Aug;118(8):592-6. doi: 10.1001/archderm.118.8.592.


A unique pigmented lesion, judged to be a hamartoma of neural crest origin, occurring in a female patient, is compared with equine melanotic disease, The characteristic perifollicular arrangement of pigment-laden spindle cells is remarkably similar in both. Previously described patch- and plaque-like blue nevi in humans are also closely related. Light and ultrastructural features showed differentiation toward both nevus cells and Schwann cells, and it is proposed that the lesion be termed pilar neurocristic hamartoma.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Animals
  • Female
  • Hair Diseases / embryology
  • Hair Diseases / pathology*
  • Hamartoma / embryology
  • Hamartoma / pathology*
  • Hamartoma / ultrastructure
  • Horse Diseases / pathology
  • Horses
  • Humans
  • Melanosis / pathology
  • Melanosis / veterinary
  • Neural Crest
  • Nevus, Pigmented / pathology
  • Skin Neoplasms / embryology
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / ultrastructure