Tetrodotoxin resistant propagation and extracellular sodium changes during spreading depression in rat cerebellum

Brain Res. 1982 Jun 10;241(2):329-33. doi: 10.1016/0006-8993(82)91071-x.


Spreading depression (SD) was elicited in the benzoate-conditioned rat cerebellum by microinjection of KC1. Median SD propagation velocity was 9.2 mm . min-1. [Na+]0 decreases, median value 77.5 mM, were measured with ion-selective micropipettes. Superfusion of the cerebellum with 10-5 M tetrodotoxin did not modify the propagation velocity or decrease the [Na+]0 change. This confirms that classical voltage-mediated Na+ conductances are not involved in SD.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cerebellum / drug effects
  • Cerebellum / physiology*
  • Cortical Spreading Depression / drug effects*
  • Female
  • Potassium Chloride / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Sodium / metabolism*
  • Tetrodotoxin / pharmacology*


  • Tetrodotoxin
  • Potassium Chloride
  • Sodium