Abstract
High blood acetaldehyde levels in alcoholics after ethanol ingestion are due to reduced acetaldehyde oxidation rather than to an increased rate of its formation from ethanol. This is associated with low hepatic acetaldehyde dehydrogenase activity in alcoholic subjects and may represent a specific abnormality in them.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetaldehyde / blood*
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Adult
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Alcoholism / blood
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Alcoholism / enzymology
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Alcoholism / metabolism*
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Aldehyde Oxidoreductases / metabolism*
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Ethanol / blood
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Humans
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Lactates / blood
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Lactic Acid
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Liver / enzymology*
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Male
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Middle Aged
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Pyruvates / blood
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Pyruvic Acid
Substances
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Lactates
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Pyruvates
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Lactic Acid
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Ethanol
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Pyruvic Acid
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Aldehyde Oxidoreductases
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aldehyde dehydrogenase (NAD(P)+)
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Acetaldehyde