The attenuation of exercise-induced bronchospasm by ascorbic acid

Ann Allergy. 1982 Sep;49(3):146-51.


In order to study the potential benefit of ascorbic acid in asthma we investigated its role in exercise-induced bronchospasm (EIB). Twelve asthmatic subjects were recruited on the basis of findings compatible with EIB. On two subsequent days the subjects ingested 500 mg. of ascorbic acid or a placebo. The study was performed in a double-blind randomized fashion. Partial and maximal expiratory flow volume (PEFV and MEFV) curves were used to determine pulmonary function changes. Pretreatment with ascorbic acid led to a significant attenuation of the bronchospasm seen five minutes after exercise compared to placebo, as measured by FVC (0.23 +/- 0.08 L decrease after ascorbic acid, 0.48 +/- 0.14 L decrease after placebo) and by FEV1 (0.24 +/- 0.06 decrease after ascorbic acid, 0.44 +/- 0.14 decrease after placebo) Mean +/- SE). These results suggest a mild antibronchospastic action of ascorbic acid in subjects with EIB.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Ascorbic Acid / therapeutic use*
  • Asthma / drug therapy*
  • Asthma, Exercise-Induced / diagnosis
  • Asthma, Exercise-Induced / drug therapy*
  • Female
  • Forced Expiratory Volume
  • Humans
  • Male
  • Maximal Expiratory Flow-Volume Curves
  • Placebos
  • Vital Capacity


  • Placebos
  • Ascorbic Acid