Abstract
Preexposure of rabbits to Mycoplasma arthritidis predisposed them to subsequent development of chronic inflammation in knee joints challenged with nonviable M arthritidis antigens. Rabbits sensitized by hyperimmunization developed a more severe arthritis than those sensitized by infection. Unsensitized rabbits responded minimally to intraarticular injection of nonviable organisms. These results suggested that an immune response to a persisting mycoplasmal antigen might be capable of sustaining chronic inflammation in rabbits with arthritis induced by viable M arthritidis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Bacterial / analysis
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Antigens, Bacterial / immunology*
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Arthritis, Infectious / etiology
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Arthritis, Infectious / immunology*
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Arthritis, Infectious / pathology
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Cartilage, Articular / immunology
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Complement C3 / immunology
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Female
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Immunoglobulin G / immunology
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Knee Joint / pathology
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Lymphocyte Activation
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Mycoplasma / immunology
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Rabbits
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Spleen / cytology
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Synovial Membrane / immunology
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Complement C3
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Immunoglobulin G