Evaluation of a continuous oestrogen-progestogen regimen for climacteric complaints

Maturitas. 1982 Aug;4(2):95-102. doi: 10.1016/0378-5122(82)90035-4.


Subjective complaints, endometrial histopathology, vaginal cytology and bleeding patterns were recorded in 26 patients treated with a continuous oestrogen-progestogen regimen for 12 mth. A marked reduction of hot flushes and sweats were noted and the evaluation of endometrial specimens revealed that the mucosae were mostly inactive-atrophic. The karyopyknotic index proved to be a poor indicator of oestrogenic activity. The number of recorded bleedings in the peri-menopausal women differed markedly from the post-menopausal women during treatment; they were very slight in the latter group. Even in those cases where bleeding occurred, the endometrial samples were found to be atrophic. Vaginal bleeding seemed to be an unreliable indicator of endometrial histopathology. The present combination of hormones used in a continuous regimen is a good alternative for post-menopausal women in need of hormonal therapy.

MeSH terms

  • Climacteric / drug effects*
  • Estradiol / adverse effects*
  • Estradiol / therapeutic use*
  • Female
  • Humans
  • Middle Aged
  • Norethindrone / adverse effects
  • Norethindrone / analogs & derivatives*
  • Norethindrone / therapeutic use
  • Norethindrone Acetate
  • Uterine Hemorrhage / chemically induced
  • Vagina / cytology
  • Vaginal Smears


  • Estradiol
  • Norethindrone Acetate
  • Norethindrone