Remissions induced in hereditary angioneurotic edema with an attenuated androgen (danazol): correlation between concentrations of C1-inhibitor and the forth and second components of complement

J Lab Clin Med. 1978 Oct;92(4):501-7.


Serum concentrations of antigenic and functional C1-INH increased in patients in whom remissions from attacks of HANE were induced with danazol. The levels of C4 were directly related to serum concentrations of C1-INH antigens up to a concentration of about half the C1-INH found in normal plasma; at this point, the C4 concentrations were in the normal range and no longer correlated well with C1-INH concentration. Serum C2 levels correlated less well with C1-INH concentration. In normal serum there was a poor correlation between C1-INH, C4, and C2 levels, suggesting that C1-INH is normally present in excess of the amount needed for normal C4 levels. The increments in serum C1-INH were related to the dose of danazol.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Angioedema / blood
  • Angioedema / drug therapy*
  • Angioedema / genetics
  • Complement C1 Inactivator Proteins / metabolism*
  • Complement C2 / metabolism*
  • Complement C4 / metabolism*
  • Danazol / therapeutic use*
  • Humans
  • Pregnadienes / therapeutic use*
  • Remission, Spontaneous


  • Complement C1 Inactivator Proteins
  • Complement C2
  • Complement C4
  • Pregnadienes
  • Danazol