The effect of leukotriene C4 and D4 on cutaneous blood flow in humans

Prostaglandins. 1982 Jun;23(6):797-801. doi: 10.1016/0090-6980(82)90124-1.


Using a laser-Doppler-flowmeter the microvascular response to LTC4 and LTD4 was measured. Intradermal injection of 1 microgram LTC4 and LTD4 caused an increase in the microvascular cutaneous bloodflow. The increase in flow was equal to that caused by histamine in equimolar amounts. Blocking the triple-response did not change the response. The values measured after injection of histamine and leucotrienes were about 10-15 times the values found in undisturbed skin and represents probably a maximally dilated vascular bed. Injection of the leucotrienes caused a slight sensation of pain.

MeSH terms

  • Adult
  • Humans
  • Injections, Intradermal
  • Lasers
  • Microcirculation / drug effects
  • Middle Aged
  • Regional Blood Flow / drug effects
  • SRS-A / administration & dosage
  • SRS-A / pharmacology*
  • Skin / blood supply*


  • SRS-A