Bronchial hyperreactivity in cystic fibrosis and asthma

J Pediatr. 1978 Nov;93(5):744-8. doi: 10.1016/s0022-3476(78)81070-1.


We studied 113 patients with CF and compared their responsiveness to inhaled methacholine to that of 50 asthmatic children and 26 normal children. Positive responses to MCh occurred in 51% of the patients with CF and 98% of those with asthma. There was a significant correlation between a positive response to MCh in CF and poor pulmonary function. There was no relationship between allergic rhinitis or positive allergen skin tests and a positive MCh response. Dose-response curves and time course to MCh challenge differed in CF and asthma. Bronchial hyperreactivity is thus common in CF but is different from that in asthma.

MeSH terms

  • Adolescent
  • Adult
  • Asthma / immunology
  • Asthma / physiopathology*
  • Bronchi / drug effects*
  • Bronchi / immunology
  • Bronchi / physiopathology
  • Child
  • Cystic Fibrosis / genetics
  • Cystic Fibrosis / immunology
  • Cystic Fibrosis / physiopathology*
  • Dose-Response Relationship, Drug
  • Female
  • Forced Expiratory Volume
  • Histamine / pharmacology
  • Humans
  • Male
  • Methacholine Compounds / pharmacology*


  • Methacholine Compounds
  • Histamine