A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands

Arch Gen Psychiatry. 1982 Oct;39(10):1157-67. doi: 10.1001/archpsyc.1982.04290100031006.


In a family study of 1,254 adult relatives of patients and controls, lifetime prevalences of major affective disorder (including schizoaffective) were 37%, 24%, 25%, 20% and 7% in relatives of probands with schizoaffective, bipolar I, bipolar II, and unipolar disease, and normal controls. These data were compatible with the different affective disorders representing thresholds on a continuum of underlying multifactorial vulnerability. In this model, schizoaffective illness represents greatest vulnerability, followed by bipolar I and bipolar II, then unipolar illnesses. Alcoholism, drug abuse, and sociopathy were not more frequent in relatives of patients v relatives of controls. Sex-related transmission of morbid risk was not present. Morbid risk was 74% to offspring of two III parents, and 27% to offspring of one III parent. Nationality and age at time of interview seem to be nongenetic factors that affect frequency of diagnosis.

MeSH terms

  • Adult
  • Age Factors
  • Alcoholism / genetics
  • Antisocial Personality Disorder / genetics
  • Bipolar Disorder / genetics*
  • Depressive Disorder / genetics*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Models, Genetic
  • Pedigree
  • Psychotic Disorders / genetics*
  • Risk
  • Sex Factors
  • Substance-Related Disorders / genetics