23, 25, 26-trihydroxycholecalciferol. A 25-hydroxycholecalciferol-26,23-lactone precursor

Biochem J. 1982 Jul 15;206(1):173-6. doi: 10.1042/bj2060173.

Abstract

(23S)-23,25-Dihydroxycholecalciferol was converted into at least five metabolites in kidney homogenates prepared from 1,25-dihydroxycholecalciferol-treated chickens. One of these has been positively identified as 23,25,26-trihydroxycholecalciferol by u.v.-absorbance analysis, mass spectrometry and chemical formation of derivatives. 23,25,26-Trihydroxycholecaciferol produces 25-hydroxycholecalciferol-26,23-lactone when incubated in chick kidney homogenates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Calcifediol / analogs & derivatives*
  • Calcifediol / metabolism
  • Chickens
  • Hydroxycholecalciferols / metabolism*
  • In Vitro Techniques
  • Kidney / metabolism*
  • Mass Spectrometry

Substances

  • Hydroxycholecalciferols
  • calcifediol lactone
  • 23,25,26-trihydroxyvitamin D3
  • Calcifediol