Prediction of intestinal first-pass effect of phenacetin in the rat from enzyme kinetic data--correlation with in vivo data using mucosal blood flow

Biochem Pharmacol. 1982 Aug 1;31(15):2545-8. doi: 10.1016/0006-2952(82)90068-5.
No abstract available

MeSH terms

  • Animals
  • Dealkylation
  • Intestinal Mucosa / blood supply*
  • Intestinal Mucosa / metabolism
  • Kinetics
  • Male
  • Methylcholanthrene / pharmacology
  • Phenacetin / metabolism*
  • Rats
  • Rats, Inbred Strains
  • Regional Blood Flow

Substances

  • Methylcholanthrene
  • Phenacetin