Alteration of plasma prednisolone levels by indomethacin and naproxen

Br J Clin Pharmacol. 1982 Sep;14(3):459-61. doi: 10.1111/j.1365-2125.1982.tb02010.x.


Eleven patients with stable rheumatoid disease (RD) who were receiving regular corticosteroid therapy (CS) were investigated to discover the effect on plasma prednisolone levels of additional therapy with the non-steroidal anti-inflammatory (NSAI) drugs, indomethacin and naproxen. There was a highly significant (P less than 0.001) increase in free prednisolone levels after concurrent therapy with either indomethacin or naproxen for 2 weeks. Total prednisolone levels were unchanged. These results could provide an explanation for clinical reports that these two NSAI drugs possess a steroid-sparing effect.

MeSH terms

  • Aged
  • Female
  • Humans
  • Indomethacin / pharmacology*
  • Male
  • Middle Aged
  • Naproxen / pharmacology*
  • Prednisolone / blood*
  • Protein Binding


  • Naproxen
  • Prednisolone
  • Indomethacin