G gamma and a gamma globin chain synthesis in bone marrow and peripheral blood of beta-thalassaemia homozygotes

Br J Haematol. 1982 Oct;52(2):225-31. doi: 10.1111/j.1365-2141.1982.tb03884.x.


G gamma, A gamma and beta globin chain synthesis has been investigated in the peripheral blood and bone marrow from eight beta-thalassaemia homozygotes. In five out of eight cases total gamma chain synthesis was higher in the peripheral blood than in the bone marrow; in seven out of eight cases A gamma chain synthesis was markedly higher in the marrow than in the peripheral blood. These data suggest that ineffective erythropoiesis selects F-cells synthesizing the largest amounts of G gamma chains, while A gamma producing cells are preferentially destroyed in the marrow.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Alanine / metabolism
  • Blood Cells / metabolism
  • Bone Marrow / metabolism*
  • Cells, Cultured
  • Female
  • Globins / biosynthesis*
  • Glycine / metabolism
  • Homozygote
  • Humans
  • Isoelectric Focusing
  • Male
  • Thalassemia / metabolism*


  • Globins
  • Alanine
  • Glycine