Procainamide elimination kinetics in pediatric patients

Clin Pharmacol Ther. 1982 Nov;32(5):607-11. doi: 10.1038/clpt.1982.210.

Abstract

Procainamide kinetics were studied in six children after a single intravenous dose. Two-compartment kinetic analysis of serum concentration-time curves of five children, who received a dose of 5.5 +/- 0.9 mg/kg (mean +/- SD), revealed the following values for kinetic parameters: distribution half-life, 10.3 +/- 3.4 min; elimination half-life, 1.7 +/- 0.1 hr; elimination constant, 1.2 +/- 0.3 hr-1; plasma clearance 19.4 +/- 2.0 ml/min/kg, and steady-state volume of distribution, 2.2 +/- 0.3 l/kg. A sixth patient, who received an accidental overdose of 28 mg/kg, had altered elimination kinetics due to drug-induced hypotension. N-acetylprocainamide (NAPA) was detected in serum samples obtained soon after procainamide dosing and peak concentrations were attained at 1 to 2 hr. NAPA levels were lower than corresponding procainamide concentrations at most sampling periods. The findings of short elimination half-life and rapid plasma clearance of procainamide in children suggest that continuous intravenous infusion may be necessary to maintain therapeutically effective plasma concentrations in these patients.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Arrhythmias, Cardiac / drug therapy
  • Child
  • Half-Life
  • Humans
  • Kinetics
  • Male
  • Procainamide / metabolism*
  • Procainamide / therapeutic use
  • Prospective Studies

Substances

  • Procainamide