Variations in responses to non-steroidal anti-inflammatory drugs

Br J Clin Pharmacol. 1982 Nov;14(5):691-4. doi: 10.1111/j.1365-2125.1982.tb04958.x.


1 This paper assesses the variability in the response of patients with rheumatoid disease to a group of non-steroidal anti-inflammatory drugs (NSAID). 2 Thirty six patients were divided into three groups and each group received a set of four NSAID. The different drugs were each given three times daily for a week and the treatment order was randomised. 3 The study demonstrated marked variability and unpredictability in patient responses and cast doubt on the value of comparative trials of different NSAID.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Analysis of Variance
  • Anti-Inflammatory Agents / therapeutic use*
  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / physiopathology
  • Female
  • Humans
  • Male
  • Middle Aged


  • Anti-Inflammatory Agents