Artificial sweeteners and human bladder cancer

Lancet. 1977 Sep 17;2(8038):578-81. doi: 10.1016/s0140-6736(77)91428-3.


A positive association between the use of artificial sweetners, particularly saccharin, and risk of bladder cancer in males has been observed in a case-control study of 480 men and 152 women in three Provinces in Canada. The risk ratio for ever versus never used is 1-6 for males (P=0-009, one-tailed test), and a significant dose-response relationship was obtained for both duration and frequency of use. The population attributable risk for males is estimated at 7%, though for diabetics, who have a similar risk ratio for artificial sweetner use as non-diabetics, the attributable risk is 33%.

Publication types

  • Comparative Study

MeSH terms

  • British Columbia
  • Cyclamates / administration & dosage
  • Cyclamates / adverse effects
  • Diet Surveys
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Male
  • Newfoundland and Labrador
  • Nova Scotia
  • Risk
  • Saccharin / administration & dosage
  • Saccharin / adverse effects*
  • Sex Ratio
  • Surveys and Questionnaires
  • Time Factors
  • Urinary Bladder Neoplasms / chemically induced*
  • Urinary Bladder Neoplasms / epidemiology


  • Cyclamates
  • Saccharin