Age-related changes in the corneal endothelium of the rat

Exp Gerontol. 1982;17(3):179-83. doi: 10.1016/0531-5565(82)90023-7.


The endothelial cells of the rat cornea show a progressive decline in numbers and an increase in pleomorphism from age 6 months to 30 months. These age-related changes correspond closely to those reported in the human cornea from approximately age 20 to age 70 years. The corneal endothelium may be found useful as an index of physiological aging in these and other mammals.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging*
  • Animals
  • Cell Count
  • Cornea / anatomy & histology*
  • Endothelium / anatomy & histology
  • Female
  • Microscopy, Electron, Scanning
  • Microvilli / ultrastructure
  • Rats
  • Rats, Inbred Strains