Pharmacokinetics of amoxicillin in subjects with normal and impaired renal function

Int J Clin Pharmacol Ther Toxicol. 1982 Oct;20(10):447-53.


The pharmacokinetics of amoxicillin was investigated in 4 healthy volunteers and in 16 patients with varying degrees of renal impairment, 4 of whom were on regular hemodialysis. Amoxicillin was administered both in a 1-g single intravenous injection and two 500-mg capsules per os. The kinetics of the antibiotic followed an open two-compartment model. In the patients with renal failure there was a significant decrease in beta, kappa10, and total body clearance. A linear relationship between beta of amoxicillin and creatinine clearance was found. This relationship allows dosage regimen adjustment for patients with renal impairment. A significant increase in the absorption half-life of the antibiotic was also observed in patients with renal impairment. The half-life of the antibiotic during hemodialysis was 2.3 h.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Amoxicillin / metabolism*
  • Creatinine / metabolism
  • Female
  • Half-Life
  • Humans
  • Kidney Diseases / metabolism*
  • Kidney Failure, Chronic / metabolism
  • Kinetics
  • Male
  • Middle Aged


  • Amoxicillin
  • Creatinine