The influence of psychological factors on the immune system

Med Hypotheses. 1982 Sep;9(3):331-5. doi: 10.1016/0306-9877(82)90163-3.


It is postulated that psychological factors such as emotions, stress, life experiences, etc. can produce an abnormality in immune function through mediation of the neuroendocrine system, and in the final analysis, exert control over the immune system. Studies reported in the literature are used for documentation and illustrative purposes. Further research dealing with an identification of psychological factors which lower and increase susceptibility to disease is advised.

MeSH terms

  • 17-Hydroxycorticosteroids / urine
  • Adaptation, Psychological
  • Animals
  • Depressive Disorder / immunology*
  • Grief
  • Humans
  • Immunocompetence*
  • Life Change Events
  • Mice
  • Rats
  • Stress, Psychological / immunology*


  • 17-Hydroxycorticosteroids