Stevens-Johnson syndrome in children

Pediatr Infect Dis. May-Jun 1982;1(3):155-8. doi: 10.1097/00006454-198205000-00005.

Abstract

During a 22-year period 51 cases of Stevens-Johnson syndrome (SJS) occurred in infants and children who ranged in age from 3 months to 14 years. Fifty-six percent of patients had an antecedent upper respiratory tract infection or non-specific viral infection, and 67% had received a prescription medication in the 3 weeks before onset of SJS. Nineteen patients (37%) were treated with adrenocorticosteroid medication during their hospitalization. Age, sex, duration of illness, body temperature on admission and history of antecedent medication were similar for the steroid- and non-steroid-treated patients. Rates of infection and overall complications were significantly greater in steroid-treated patients than in those treated symptomatically. These observations suggest that steroid drugs should not be used for treatment of SJS in infants and children.

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / therapeutic use
  • Anti-Bacterial Agents / therapeutic use
  • Anticonvulsants / therapeutic use
  • Bacterial Infections / etiology
  • Child
  • Child, Preschool
  • Female
  • Fluid Therapy
  • Humans
  • Infant
  • Male
  • Stevens-Johnson Syndrome / complications
  • Stevens-Johnson Syndrome / diagnosis
  • Stevens-Johnson Syndrome / therapy*

Substances

  • Adrenal Cortex Hormones
  • Anti-Bacterial Agents
  • Anticonvulsants