Radioimmunoassay of serum group I and group II pepsinogens in normal controls and patients with various disorders

Clin Chim Acta. 1982 Dec 9;126(2):183-91. doi: 10.1016/0009-8981(82)90034-1.


A radioimmunoassay (RIA) for human group I pepsinogens (PgI) in serum was developed, using PgI purified from gastric mucosa. The sensitivity (0.7 micrograms/l) and reproducibility of the assay were satisfactory for clinical use. In normal controls, total serum pepsinogen (T-Pg) level was 58.9 +/- 31.7 micrograms/l (mean +/- SD) (PgI, 43.6 +/- 25.0 micrograms/l; PgII, 15.3 +/- 11.1 micrograms/l). Peptic ulcer cases had elevated T-Pg levels (gastric ulcer, gastroduodenal ulcer and duodenal ulcer, in increasing order of magnitude). T-Pg levels were not useful for diagnosis of peptic ulcer because of a large overlap with normal controls. T-Pg levels were low in patients with gastric polyp and in aged subjects. In these groups, the decrease of PgI was more marked than that of PgII.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aging
  • Duodenal Ulcer / blood
  • Female
  • Gastrectomy
  • Humans
  • Kidney Failure, Chronic / blood
  • Male
  • Middle Aged
  • Pepsinogens / blood*
  • Peptic Ulcer / blood*
  • Polyps / blood
  • Radioimmunoassay* / standards
  • Stomach Neoplasms / blood
  • Stomach Ulcer / blood


  • Pepsinogens