Toxicological effects of chlorite in the mouse

Environ Health Perspect. 1982 Dec;46:31-7. doi: 10.1289/ehp.824631.


When exposed to a maximum level of 100 ppm chlorine dioxide in their drinking water, neither A/J or C57L/J mice exhibited any hematologic changes. Chlorite exposure under similar conditions produced increases for red blood cells in osmotic fragility, mean corpuscular volume, and glucose-6-phosphate dehydrogenase activity for both strains. Chlorite exposure of pregnant A/J mice resulted in a significant decrease in the weight of pups at weaning and a lower average birth to weaning growth rate. Mice exposed to as much as 100 ppm sodium chlorite (NaClO2) in their drinking water for up to 120 days failed to demonstrate any histopathological changes in kidney structure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Birth Weight / drug effects
  • Chlorides / toxicity*
  • Chlorine / toxicity*
  • Chlorine Compounds*
  • Female
  • Fetus / drug effects*
  • Glucosephosphate Dehydrogenase / metabolism
  • Kidney / drug effects
  • Kidney / pathology
  • Maternal-Fetal Exchange
  • Mice
  • Mice, Inbred A
  • Mice, Inbred C57BL
  • Osmotic Fragility / drug effects
  • Oxides / toxicity*
  • Pregnancy


  • Chlorides
  • Chlorine Compounds
  • Oxides
  • Chlorine
  • chlorine dioxide
  • Glucosephosphate Dehydrogenase
  • chlorite