Induction of prostate adenocarcinomas in Lobund Wistar rats by testosterone

Prostate. 1982;3(6):563-8. doi: 10.1002/pros.2990030605.


Prostate adenocarcinomas were induced in Lobund Wistar rats following subcutaneous implants of silastic chambers containing testosterone propionate. The tumors resembled those that developed spontaneously in the Lobund Wistar rats. Tumors were not induced in ACI rats by the same treatment schedule.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma / chemically induced*
  • Adenocarcinoma / pathology
  • Animals
  • Male
  • Neoplasms, Experimental / chemically induced
  • Neoplasms, Experimental / pathology
  • Prostatic Neoplasms / chemically induced*
  • Prostatic Neoplasms / pathology
  • Rats
  • Rats, Inbred Strains
  • Testosterone / adverse effects*


  • Testosterone