Is hyperviscosity a treatable component of diabetic microcirculatory disease?

Lancet. 1977 Oct 15;2(8042):789-91. doi: 10.1016/s0140-6736(77)90724-3.

Abstract

Blood viscosity at low shear-rates was significantly higher in sixty-four patients with longstanding diabetes than in sixty-one matched non-diabetic controls. This increase was most striking in patients with either proliferative retinopathy or nephropathy, although it was present to a lesser extent in diabetic patients with evidence of myocardial or peripheral ischaemia. Erythrocyte deformability was lower in the fourteen diabetic patients with the most extensive microangiopathy than in twenty-two diabetics with slight or no complications or in controls. Hyperviscosity and reduced erythrocyte deformability may well be important and potentially treatable factors in the aetiology or progression of microcirculatory disease is diabetes.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aneurysm / blood*
  • Blood Glucose / analysis
  • Blood Proteins / analysis
  • Blood Viscosity*
  • Capillaries
  • Creatinine / blood
  • Diabetic Angiopathies / blood*
  • Diabetic Nephropathies / blood
  • Diabetic Neuropathies / blood
  • Diabetic Retinopathy / blood
  • Diabetic Retinopathy / therapy
  • Erythrocytes, Abnormal / pathology
  • Female
  • Hematocrit
  • Humans
  • Ischemia / blood
  • Lipids / blood
  • Male
  • Microcirculation
  • Middle Aged
  • Myocardial Infarction / blood
  • Urea / blood

Substances

  • Blood Glucose
  • Blood Proteins
  • Lipids
  • Urea
  • Creatinine