Combination therapy of murine tumors with lentinan plus lipopolysaccharide plus cyclophosphamide

Gan. 1982 Dec;73(6):961-7.


A combination of lentinan and bacterial lipopolysaccharide (LPS), previously reported to have strong antitumor activity against some tumors, was only slightly effective on solid-type MH134 hepatoma and colon 38 adenocarcinoma and was not effective on ascitic L1210 in CDF1 mice. On the other hand, additional combination therapy with cyclophosphamide (CY), that is, lentinan plus LPS plus CY, strongly inhibited the growth of solid-type MH134 and colon 38 adenocarcinoma even when administered from day 12 after tumor inoculation. The antitumor delayed hypersensitivity reaction against MH134 hepatoma, measured by means of the footpad test, was augmented by this combination. The possible role of CY is discussed in relation to the importance of inhibition of immune suppressive mechanisms in this combination therapy.

MeSH terms

  • Adenocarcinoma / drug therapy
  • Animals
  • Antineoplastic Agents*
  • Cell Line
  • Cyclophosphamide / administration & dosage*
  • Drug Therapy, Combination
  • Lentinan / administration & dosage*
  • Leukemia L1210 / drug therapy
  • Lipopolysaccharides / administration & dosage*
  • Liver Neoplasms, Experimental / drug therapy
  • Mice
  • Mice, Inbred Strains
  • Neoplasm Transplantation
  • Neoplasms, Experimental / drug therapy*
  • Neoplasms, Experimental / immunology
  • Neoplasms, Experimental / pathology
  • Polysaccharides / administration & dosage*
  • Prognosis


  • Antineoplastic Agents
  • Lipopolysaccharides
  • Polysaccharides
  • Lentinan
  • Cyclophosphamide