Indomethacin by intravenous infusion in ureteral colic. A multicentre study

Scand J Urol Nephrol. 1982;16(3):221-5. doi: 10.3109/00365598209179757.


In a multicentre study the analgetic effect of indomethacin in ureteral colic was analyzed. Indomethacin, which inhibits the synthesis of prostaglandin, was given by intravenous infusion in a dose of 50 mg. The study comprised 198 patients with 252 attacks of ureteral colic. Satisfactory relief of pain was obtained in 212 attacks (84%). No serious side effects of indomethacin were observed. The pain recurred within four hours in only 15 patients (7%), in 12 of them during a diagnostic intravenous pyelography. The relief of pain may be explained by reduced glomerular filtration pressure and/or diminished urinary excretion, causing rapid fall in the renal pelvic pressure and in the tension of the pelvi-ureteral wall. A low extracellular volume of fluid in a patient with ureteral colic may be essential for analgetic action of indomethacin.

MeSH terms

  • Adult
  • Aged
  • Blood Pressure / drug effects
  • Colic / drug therapy*
  • Female
  • Humans
  • Indomethacin / administration & dosage
  • Indomethacin / adverse effects
  • Indomethacin / therapeutic use*
  • Infusions, Parenteral
  • Kidney Pelvis / physiopathology
  • Male
  • Middle Aged
  • Pressure
  • Ureteral Diseases / drug therapy*


  • Indomethacin