Comparison of the delayed neurotoxicity of O-methyl and O-ethyl analogs of EPN, leptophos, and cyanofenphos

J Environ Sci Health B. 1982;17(6):611-33. doi: 10.1080/03601238209372346.

Abstract

Eight pairs of O-methyl and O-ethyl O-(substituted-phenyl) phenylphosphonothionates were evaluated with respect to their delayed neurotoxic activity in hens. O-methyl compounds were in all cases more active than their O-ethyl analogs. The neurotoxic potential of the O-methyl phenylphosphonothionates was 2,5-diCl greater than 4-NO2 greater than 2,4,5-triCl and 2,4,6-triCl greater than 2,4-diCl greater than 2,5-diCl-4-Br greater than 4-CN, when single oral doses were given. Both EPN-ethyl and leptophos-methyl were more neurotoxic in multiple dermal than multiple oral dosing regimens. LD50s for mice and flies were established.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Administration, Topical
  • Animals
  • Ataxia / chemically induced
  • Chickens
  • Diptera
  • Female
  • Lethal Dose 50
  • Mice
  • Nervous System / drug effects*
  • Organophosphorus Compounds / administration & dosage
  • Organophosphorus Compounds / toxicity*
  • Species Specificity
  • Time Factors

Substances

  • Organophosphorus Compounds