Anti-C-carbohydrate Antibodies After Pneumococcal Vaccination

Acta Pathol Microbiol Immunol Scand C. 1982 Dec;90(6):353-5. doi: 10.1111/j.1699-0463.1982.tb01462.x.

Abstract

Similar levels of naturally occurring anti-pneumococcal C-carbohydrate antibodies were found in 15 splenectomized children, 10 splenectomized adults and 12 healthy adult volunteers by enzymelinked immunosorbent assay. Vaccination with a 14-valent pneumococcal capsular polysaccharide vaccine (Pneumovax) that contains approximately 75 micrograms C-carbohydrate per dose only led to small anti-C-carbohydrate antibody increases; they were significant, however, for all three groups (p less than 0.05) but antibody fold increases were below 2 in 34 of the 37 individuals studied.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Bacterial / biosynthesis*
  • Bacterial Vaccines / administration & dosage*
  • Bacterial Vaccines / immunology
  • Child
  • Child, Preschool
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Middle Aged
  • Pneumococcal Vaccines
  • Polysaccharides, Bacterial / immunology*
  • Vaccination*

Substances

  • Antibodies, Bacterial
  • Bacterial Vaccines
  • Pneumococcal Vaccines
  • Polysaccharides, Bacterial
  • polysaccharide C-substance (Streptococcus)