The locus coeruleus: a quantitative and genetic study in mice

Brain Res. 1982 Nov 4;250(2):353-7. doi: 10.1016/0006-8993(82)90430-9.


A fluorescence histochemical study of the pontine catecholaminergic (CA) neurons of two inbred strains of mice, BALB/c (C) and C57BL/6 (B6) and their F1 hybrids revealed that the total number of the fluorescent cells in the C strain was 38% lower than that of the B6 strain. In F1 hybrids, the total number of neurons was not statistically different from that of the B6 parent. During the development from birth to adulthood, the same quantitative differences between strains were observed.

MeSH terms

  • Animals
  • Catecholamines / metabolism
  • Cell Count
  • Female
  • Genotype*
  • Hybridization, Genetic
  • Locus Coeruleus / cytology*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Microscopy, Fluorescence
  • Neurons / cytology
  • Pons / cytology
  • Sleep Stages / physiology


  • Catecholamines