Nucleolar specific acidic phosphoprotein C23 is highly methylated

J Biol Chem. 1982 Dec 25;257(24):14600-2.

Abstract

Protein C23 (Mr = 110,000; pI, 5.5) is the major phosphoprotein in the nucleolus of Novikoff hepatoma cells and comprises 9.5% of the total nucleolar protein. In addition to being highly phosphorylated (1.2 mol % of phosphoserine), it is also highly methylated. Protein C23 contains 1.3 mol % of NG,NG-dimethylarginine and a trace of NG-monomethylarginine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acids / analysis
  • Animals
  • Arginine / analogs & derivatives
  • Arginine / analysis
  • Cell Nucleolus / analysis*
  • Liver Neoplasms, Experimental / analysis*
  • Methylation
  • Molecular Weight
  • Phosphoproteins / isolation & purification*
  • Rats

Substances

  • Amino Acids
  • Phosphoproteins
  • phosphoprotein C23
  • symmetric dimethylarginine
  • 2-methylarginine
  • Arginine