Intestinal absorption of polyenephosphatidylcholine in man

J Lipid Res. 1982 Nov;23(8):1136-42.

Abstract

The metabolic fate of 1 of 3H/14C-labeled dilinoleoglycerophosphocholine was studied in five patients after oral administration. The 3H label was in choline and 14C was in the two linoleic acid residues. More than 90% of both isotopes was absorbed from the intestine. Seventy to 90% of the 3H radioactivity in blood was linked to phosphatidylcholine (PC) whereas 14C was associated with both PC and nonpolar lipids. At peak activity, the 3H/14C ratio of plasma PC was twice that of oral PC; this suggests that most oral PC was hydrolyzed to lysolecithin before absorption. The mean maximum concentration in total blood volume was 20% of the administered dose for 3H and 28% for 14C. Examination of lipoproteins revealed that the specific activity of PC in high density lipoprotein (HDL) was 2 to 6 times higher than in apoB-containing lipoproteins, and to 2 to 20 times than that of red blood cells or total blood. Thus, absorbed PC seemingly was incorporated preferentially into the HDL fraction of plasma.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Absorption
  • Feces / analysis
  • Female
  • Humans
  • Intestinal Absorption*
  • Kinetics
  • Lipoproteins / blood
  • Male
  • Middle Aged
  • Phosphatidylcholines / metabolism*
  • Time Factors

Substances

  • Lipoproteins
  • Phosphatidylcholines
  • polyene phosphatidylcholine