Theophylline bioavailability in the dog

J Pharm Sci. 1982 Nov;71(11):1301-3. doi: 10.1002/jps.2600711132.


The bioavailability of theophylline following single oral doses of a theophylline capsule, a theophylline tablet, and an aminophylline tablet in beagle dogs was compared against an intravenous standard. Plasma theophylline levels after oral and intravenous drug administration were described by the one-compartment open model. The onset of theophylline absorption from the oral products was rapid. While the theophylline tablet showed a slower absorption rate than the capsule or the aminophylline tablet, all three products appeared to be completely bioavailable.

MeSH terms

  • Administration, Oral
  • Animals
  • Biological Availability
  • Dogs
  • Female
  • Injections, Intravenous
  • Kinetics
  • Male
  • Theophylline / metabolism*


  • Theophylline