Effects of lysine-vasopressin and 1-deamino-8-D-arginine-vasopressin on memory in healthy individuals and diabetes insipidus patients

Psychoneuroendocrinology. 1982;7(2-3):185-93. doi: 10.1016/0306-4530(82)90011-7.


Central diabetes insipidus (DI) patients showed impairments in short- and long-term memory functions, but not in attention and concentration, as compared to healthy individuals. A single i.m. injection or sub-chronic intranasal administration of either lysine-vasopressin (LVP) or 1-deamino-8-D-arginine-vasopressin (DDAVP) normalized the disturbed memory functions in DI patients. These peptides also improved memory functions in healthy individuals.

MeSH terms

  • Administration, Intranasal
  • Adult
  • Arginine Vasopressin / pharmacology*
  • Deamino Arginine Vasopressin / administration & dosage
  • Deamino Arginine Vasopressin / pharmacology*
  • Diabetes Insipidus / physiopathology*
  • Female
  • Humans
  • Injections, Intramuscular
  • Lypressin / administration & dosage
  • Lypressin / pharmacology*
  • Male
  • Memory / drug effects*
  • Middle Aged


  • Arginine Vasopressin
  • Lypressin
  • Deamino Arginine Vasopressin