Cholinergic agonist-induced down regulation of neuronal alpha-bungarotoxin receptors

Brain Res. 1982 Jan 28;232(2):479-84. doi: 10.1016/0006-8993(82)90292-x.

Abstract

The ability of cholinergic ligands to regulate neuronal alpha-bungarotoxin receptor number was studied in dissociated monolayer cultures of embryonic chick ciliary ganglion neurons. Carbamylcholine and nicotine, but not D-tubocurarine, caused a loss of 25% of the surface [125I]alpha-bungarotoxin receptors within 1 h at 37 degrees C. This receptor loss occurred without change in affinity for [125I]alpha-bungarotoxin, was temperature-sensitive and was prevented by co-incubation with D-tubocurarine.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bungarotoxins / metabolism
  • Carbachol / pharmacology*
  • Chick Embryo
  • Ganglia, Parasympathetic / drug effects*
  • Ganglia, Parasympathetic / metabolism
  • Kinetics
  • Nicotine / pharmacology*
  • Receptors, Cholinergic / drug effects*
  • Receptors, Cholinergic / metabolism
  • Receptors, Nicotinic*
  • Tubocurarine / pharmacology
  • alpha7 Nicotinic Acetylcholine Receptor

Substances

  • Bungarotoxins
  • Receptors, Cholinergic
  • Receptors, Nicotinic
  • alpha7 Nicotinic Acetylcholine Receptor
  • Nicotine
  • Carbachol
  • Tubocurarine