Psorospermin, a new antileukemic xanthone from Psorospermum febrifugum

J Nat Prod. Mar-Apr 1980;43(2):296-301. doi: 10.1021/np50008a010.


An ethanolic extract of Psorospermum febrifugum was fractionated with antileukemic activity in vivo in the P388 lymphocytic leukemia in mice and in vitro in the KB cell culture system used as a guide. The new antileukemic xanthone psorospermin 1 was isolated, and its structure was elucidated. The chlorohydrin of O-methylpsorospermin 2 was also isolated after treatment of the fraction containing psorospermin chlorohydrin 6 with diazomethane. Psorospermin 1 was demonstrated to have significant antitumor activity in the P388 in vivo system as well as cytotoxicity against the KB in vitro system.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Carcinoma, Squamous Cell
  • Cell Line
  • Chemical Phenomena
  • Chemistry
  • Female
  • Humans
  • Leukemia P388 / drug therapy
  • Mass Spectrometry
  • Mice
  • Mitosis / drug effects
  • Nasopharyngeal Neoplasms
  • Neoplasms, Experimental / drug therapy
  • Ovum / drug effects
  • Plants, Medicinal / analysis*
  • Sea Urchins
  • Xanthenes / isolation & purification*
  • Xanthenes / pharmacology
  • Xanthones*


  • Antineoplastic Agents, Phytogenic
  • Xanthenes
  • Xanthones
  • psorospermin