Biological properties of 16 alpha-hydroxyestrone: implications in estrogen physiology and pathophysiology

J Clin Endocrinol Metab. 1980 Sep;51(3):611-5. doi: 10.1210/jcem-51-3-611.

Abstract

Metabolism of estradiol in men with cirrhosis and subjects with systemic lupus erythematosus results in an excessive formation of 16 alpha-hydroxyestrone. Examination of the biological activity of this metabolite showed that it is a potent uterotropic agent and that it exhibits minimal affinity for the human sex hormone-binding globulin. These biological characteristics are consistent with a hyperestrongenic response to the substance, which may be reflected in the pathology and etiology of these diseases.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Castration
  • Estradiol / metabolism
  • Estriol / metabolism
  • Estrogens / pharmacology
  • Estrogens / physiology*
  • Estrone / analogs & derivatives*
  • Female
  • Hydroxyestrones / pharmacology*
  • Luteinizing Hormone / blood
  • Rats
  • Receptors, Estrogen / metabolism
  • Sex Hormone-Binding Globulin / metabolism
  • Uterus / drug effects
  • Uterus / metabolism

Substances

  • Estrogens
  • Hydroxyestrones
  • Receptors, Estrogen
  • Sex Hormone-Binding Globulin
  • 16-hydroxyestrone
  • Estrone
  • Estradiol
  • Luteinizing Hormone
  • Estriol