Effects of pyridoxine-pyrrolidon-carboxylate on hepatic and cerebral ATP levels in ethanol treated rats

Int J Clin Pharmacol Ther Toxicol. 1980 Jun;18(6):277-80.

Abstract

ATP levels were measured in the liver and brain of rats acutely intoxicated with ethanol. The pretreatment of the animals with pyridoxine-pyrrolidon carboxylate (Metadoxine) prevented the marked fall in ATP concentration caused by ethanol in both organs.

MeSH terms

  • Adenosine Triphosphate / analysis*
  • Alcoholic Intoxication / metabolism*
  • Animals
  • Brain Chemistry / drug effects*
  • Drug Combinations
  • Humans
  • Liver / analysis*
  • Liver / drug effects
  • Male
  • Pyridoxine / pharmacology*
  • Pyrrolidinones / pharmacology*
  • Pyrrolidonecarboxylic Acid / pharmacology*
  • Rats
  • Time Factors

Substances

  • Drug Combinations
  • Pyrrolidinones
  • Adenosine Triphosphate
  • Pyridoxine
  • Pyrrolidonecarboxylic Acid