Resynthesis of aspartate via glutamate was decreased 6-8-fold in rat brain spinal cord tissues due to distinct inhibition of aspartate aminotransferase in acute alcohol intoxication. Consumption of glutamic acid was distinctly increased 1.5-2-fold in tissues of the central nervous system but its metabolism was altered. Normalization occurred within 12-24 hrs after the intake of alcohol. In the state of chronic alcohol intoxication the enzymatic activity was marked increased in brain and spinal cord; in this case the response to a single alcohol administration was altered as compared with acute alcohol intoxication.