Electroacupuncture treatment of morphine-dependent mice reduces signs of withdrawal, without showing cross-tolerance

Eur J Pharmacol. 1980 Dec 19;68(4):477-81. doi: 10.1016/0014-2999(80)90423-9.


Morphine pellets (75 mg morphine base per pellet) were implanted subcutaneously in mice (B6AF1/J) and were surgically removed after 3 or 8 days. During morphine abstinence (7 h after pellet removal), the mice were treated with electroacupuncture (EA). The results indicate that EA analgesia shows no cross-tolerance to morphine. Additionally, EA reduced withdrawal behaviour (jumping) in 50% of the mice during morphine abstinence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acupuncture Therapy*
  • Animals
  • Electric Stimulation
  • Female
  • Humans
  • Mice
  • Morphine Dependence / physiopathology*
  • Substance Withdrawal Syndrome / prevention & control*