Oral contraceptive history as a risk indicator in patients with pituitary tumors with hyperprolactinemia: a case comparison study of twenty patients

Neurosurgery. 1980 Dec;7(6):571-3. doi: 10.1227/00006123-198012000-00005.

Abstract

This report presents a retrospective case comparison study of 20 hyperprolactinemic patients with pituitary adenomas treated at the Mount Sinai Hospital (1976-1079). An association between oral contraceptive (OC) use and 20 subjects with pituitary tumors was substantiated using discordant paired analysis. The comparison group consisted of appendectomy patients admitted during the same time period and matched for sex and age. The estimated relative risk was 4.0 (P less than 0.025). This study suggests that there is a significant association between OC use and pituitary tumors associated with hyperprolactinemia.

PIP: A retrospective case-comparison study of 20 hyperprolactinemic patients with pituitary adenomas is presented. Cases were from the period 1976-1979. Using discordant paired analysis, an association between oral contraceptive use and 20 subjects with pituitary tumors was substantiated. For comparison, a group of appendectomy patients admitted during the same time period and matched for sex and age was studied. An estimated relative risk of 4 (P .025) was found based on this comparison, and it is concluded that a significant association between use of oral contraceptives and pituitary tumors associated with hyperprolactinemia is suggested.

MeSH terms

  • Adenoma, Chromophobe / chemically induced*
  • Adenoma, Chromophobe / complications
  • Adenoma, Chromophobe / metabolism
  • Adult
  • Amenorrhea / etiology
  • Contraceptives, Oral / adverse effects*
  • Female
  • Galactorrhea / etiology
  • Humans
  • Pituitary Neoplasms / chemically induced*
  • Pituitary Neoplasms / complications
  • Pituitary Neoplasms / metabolism
  • Pregnancy
  • Prolactin / metabolism*
  • Retrospective Studies
  • Risk

Substances

  • Contraceptives, Oral
  • Prolactin