Abstract
The tertiary and quaternary enantiomers of 3-quinuclidinyl benzilate (QNB) were tested for atropine-like activity on the electrically stimulated guinea-pig atrium preparation. The (R)-isomers had higher affinity for muscarine-sensitive acetylcholine receptors than their corresponding (S)-analogues.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholine / pharmacology*
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Animals
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Dose-Response Relationship, Drug
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Female
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Guinea Pigs
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Heart Atria / drug effects*
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Male
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Quinuclidines / pharmacology*
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Quinuclidinyl Benzilate / pharmacology*
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Receptors, Cholinergic / drug effects*
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Receptors, Muscarinic / drug effects*
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Structure-Activity Relationship
Substances
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Quinuclidines
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Receptors, Cholinergic
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Receptors, Muscarinic
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Quinuclidinyl Benzilate
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Acetylcholine