Selectivity of an indole-hydrazide derivative as inhibitor of mouse brain type A monoamine oxidase

Arzneimittelforschung. 1981;31(10):1710-2.

Abstract

The first indole-hydrazide, 1-[2,-(3-methyl)-5-benzyloxyindolyl]carbonyl-2-isopropyl hydrazide (IH-3), that irreversibly inhibits mouse brain type A monoamine oxidase is measured by 5-hydroxytryptamine deamination. The concentration required in vitro to inhibit this isoenzyme is about 7 X 10(-8) mol/l. Other biochemical and pharmacological features of this potential antidepressant are presented.

MeSH terms

  • Animals
  • Brain / enzymology*
  • Deamination
  • Indoles / pharmacology*
  • Kinetics
  • Mice
  • Monoamine Oxidase Inhibitors*
  • Motor Activity / drug effects
  • Phenethylamines / metabolism
  • Reserpine / antagonists & inhibitors
  • Serotonin / metabolism
  • Synaptosomes / metabolism
  • Tyramine / metabolism

Substances

  • Indoles
  • Monoamine Oxidase Inhibitors
  • Phenethylamines
  • Serotonin
  • 1-(2-(3-methyl-5-benzyloxyindolyl)carbonyl)-2-isopropyl hydrazide
  • Reserpine
  • Tyramine